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Miguel de la Flor García

PhD Student

Centro de Biología Molecular Severo Ochoa

Discovery (Biological & Genetic Mechanisms)

Miguel de la Flor García was graduated in Veterinary Sciences at the Complutense University of Madrid. During his degree, he collaborated with the Departments of Genetics and Physiology and did internships at the “National Institute for Agricultural and Food Research” (INIA) and the “Margarita Salas Center for Biological Research” (CIBMS). Moreover, he delved into the developmental neurobiology field during his final degree project. He continued his academic career by obtaining a master’s degree in “Biomolecules and Molecular Biology” at the Autonomous University of Madrid, acquiring deeper knowledge about molecular biology and neurosciences. During this period he developed his master’s thesis focused on the role of GSK3-beta in adult hippocampal neurogenesis in mice. After finishing his master’s degree, he started his PhD project under the supervision of Dr. María Llorens Martín at the “Center of Molecular Biology Severo Ochoa”. During this time his research was mainly focused on adult hippocampal neurogenesis in humans. He has developed a great expertise on histology, behavioral tests, and stereotaxic injections in rodents.

Selected publications:

• Flor-García, M.*, Terreros-Roncal, J.*, Moreno-Jiménez, EP.*, Ávila, J., Rábano, Llorens-Martín, M. "Unraveling human adult hippocampal neurogenesis ". Nat Protoc. 2020 Feb;15(2):668-693. doi: 10.1038/s41596-019-0267-y. Epub 2020 Jan 8.
• Terreros-Roncal, J., Flor-García, M.*, Moreno-Jiménez, E.*, Pallas-Bazarra, N., Rabano, A., Sah, N., van Praag, H., Giacomini, D., Schinder, A., Ávila, J., Llorens-Martín, M. "Activity-dependent reconnection of adult-born granule cells in frontotemporal dementia". J Neurosci. 2019 May 27. pii: 2724-18. doi: 10.1523/JNEUROSCI.2724-18.2019.
• Flor-García, M.*, Terreros-Roncal, J.*, Moreno-Jiménez, EP.*, Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., Llorens-Martín, M. “Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease”. Nat Med. 2019 Mar 25. doi: 10.1038/s41591-019-0375-9.

Area of Research Expertise
Hippocampal neurogenesis; Histology; Behavioral tests; Stereotaxic injections