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Applied (Clinical and Engineering Applications)
Jinan Saboune is a Ph.D. student in the Cardiovascular Health and Autonomic Regulation Laboratory (CHARlab) at McGill University. Her research looks at the neurovascular changes that occur during a very critical phase in a woman's life: peri-menopause. As women age and transition into menopause, they lose most of their estrogen content, which makes them more susceptible to cardiovascular dysfunction. The goal of her research is to look at these complex hormone fluctuations, that are being exhibited during this phase, and how they contribute to worse cardiovascular outcomes.
During her MS.c in the Pyle Lab (University of Guelph), she combined multiple lab techniques to understand how the heart undergoes changes under stress. From cardiovascular physiology to using a unique mouse model of peri-menopause and back to molecular analysis, she was able to build up an understanding of how peri-menopause profoundly changes the heart as a response to pathological stress.
Transitioning into human studies, her work in the CHARLab is clinical and explores changes in muscle sympathetic nerve activity (MSNA) during peri-menopause and how this risk period contributes to worse cardiovascular outcomes in women with Polycystic Ovary Syndrome.
Jinan is currently one of the CIHR IGH Trainee Network Team Leads at McGill University. With her work, she aims to contribute to combating the generalized idea that one drug fits both sexes and move towards more acute and personalized health care to reduce cardiovascular risk in women.